• Promotes healthy sleep patterns in people suffering from sleep restriction, altered sleep schedule and delayed sleep phase disorder
• Offers MicroActive^® melatonin for sustained, six-hour support
• Made with hypoallergenic, vegan ingredients

NPN: 80076284

Promotes sleep onset and quality

• Features deodorized valerian root extract
• Convenient capsule format

Best-Rest Formula supports sleep quality and a healthy sleep cycle by encouraging an easy transition to sleep and a restful night’s sleep. This unique blend contains valerian, passion flower, chamomile, lemon balm and hops, which are traditionally used in Herbal Medicine. Double-blind trials involving valerian alone and in combination with other herbs have indicated its potential to support both sleep onset and quality. Best-Rest Formula also includes melatonin and GABA. Melatonin is a hormone produced by the pineal gland. It is synthesized in the circadian rhythm by enzymes, which are activated by darkness and depressed by light. GABA is the primary inhibitory neurotransmitter in the brain, and l-Theanine is a bioactive compound in green tea.
Suntheanine^® is a registered trademark of Taiyo International, Inc.

NPN: 80028740

• Offers ChromeMate^®, a clinically studied niacin-bound chromium complex
• Provides maitake mushroom extract, alpha lipoic acid and other premium herbal extracts
• Made with hypoallergenic, vegan ingredients

Glucose Support Formula provides a helpful combination of essential nutrients for healthy glucose support. Chromium is a critical component of Glucose Tolerance Factor (GTF), and optimal levels of chromium are essential for proper glucose metabolism. This formula offers ChromeMate^®, a unique niacin-bound chromium complex that may promote GTF activity to maintain healthy glucose metabolism. Alpha lipoic acid is a versatile nutrient that can function as antioxidant in almost any part of the body. Panax ginseng and Eleutherococcus senticosus, or eleuthero, have long been utilized in Herbal Medicine, and are standardized to provide 5% ginsenosides and 0.8% eleutherosides, respectively. The leaves of Gymnema sylvestre, which have been used in India for over 2,000 years, contain important active constituents, including the gymnemic acids. Maitake mushroom has wide-ranging health properties and contains the polysaccharide beta-d-glucan, a unique compound believed to be one of the most powerful for enhancing healthy defence system mechanisms.

NPN: 80027612

With Metafolin^® L-5-MTHF
Supports healthy hair, skin and nails

• Includes Metafolin^® L-5-MTHF and BioCell Collagen^®
• Helps in collagen formation and connective tissue production and repair
• Maintains skin resiliency, as well as hair and nail strength

Hair/Skin/Nails Ultra provides key building blocks and nutrients, such as biotin, zinc and silicon, to support skin elasticity and hydration, healthy hair, and nail strength and thickness. Biotin, zinc and silicon are integral collagen and keratin cofactors, which regulate skin elasticity; optimal levels of these nutrients have been associated with healthy hair, skin and nails. Zinc also promotes immune function in the skin, while clinical studies indicate that biotin may help reinforce the keratin structure of the nails, promoting strength and thickness. Similarly, vitamin C and copper are important factors in connective tissue formation and repair. Vitamin C supports collagen formation, while helping to counter the effects of oxidative stress along with sustained release CoQ₁₀ complex. BioCell Collagen^® is a patented, clinically researched, hydrolyzed and denatured low molecular weight type II collagen. It provides a naturally occurring matrix of hyaluronic acid (HA), chondroitin sulfate and collagen type II proteins.
Metafolin^® is a registered trademark of Merck KGaA, Darmstadt, Germany.
BioCell Collagen^® is a registered trademark of BioCell Technology LLC, Newport Beach, California USA (Protected by US and International Patents).

NPN: 80039604

Vegetarian stress relief formula

• Eleuthero is used in Herbal Medicine to improve mental and physical performance after periods of mental and physical exertion
• Includes a blend of herbs from eleuthero, rhodiola, panax ginseng, Astragalus and Ashwagandha
• Supports nutrient metabolism with pantothenic acid

Phyto-ADR is a vegetarian formula designed to provide wide-range support for mental and physical performance after periods of mental and physical exertion. Eleutherococcus senticosus, or eleuthero, is a highly recognized herb in Herbal Medicine, promoting physiological balance and resistance to stress. Eleuthero also supports physical working capacity, as suggested in clinical research. Eleuthero may achieve these actions in part by supporting optimal energy reserves. Preclinical research suggests that Eleuthero promotes the conversion of amino acids into carbohydrates and glycogen by the liver and stimulates glycogen formation in the tissues. Phyto-ADR includes other important herbs used in Herbal Medicine, such as rhodiola, panax ginseng, Astragalus and Ashwagandha. Pantothenic acid, a vitamin B5 derivative, is also provided to support proper nutrient metabolism.

NPN: 80030318

Contains ingredients with natural antioxidant properties
• Provides antioxidants to maintain good health
• Supports liver function
• Maintains immune defences

HM Complex is designed to support antioxidant defence, while promoting healthy liver and immune function. A blend of ingredients, including chlorella, lipoic acid, N-Acetyl-L-Cysteine (NAC), selenium and vitamin C, scavenges free radicals. These antioxidants may also help regulate oxidative stress induced by heavy metals – such as mercury, arsenic, cadmium, lead and tin – that results from common, mild environmental exposure. In addition, NAC provides important support for the liver by enhancing glutathione concentration. Similarly, l-methionine, an essential amino acid, supports glutathione production and encourages healthy liver function, including phase II detoxification pathways. HM Complex also contains modified citrus pectin and zinc. The unique characteristic of modified citrus pectin is that it has a low molecular weight, which allows it to easily pass through the intestinal barrier. Zinc is essential for a wide range of physiological functions and is part of a cysteine-rich metal-binding protein. By promoting healthy neutrophil, natural killer cell, and T-lymphocyte function, zinc plays an important role in supporting the body’s defence system.

NPN: 80073700

Support for moderating stress and reducing fatigue

ADR Formula^® combines whole adrenal and adrenal cortex with a blend of herbs traditionally used in Herbal Medicine, plus pantothenic acid and vitamin C. Eleuthero helps the body respond to mental and physical stress by regulating adrenal hormone function, namely corticosterone. Similarly, Panax ginseng has long been utilized to assist the body in adapting to its environment by enhancing endurance in cases of stress. During prolonged physical stress, such as exercise, Panax ginseng promotes endurance and stamina by sparing carbohydrates and allowing skeletal muscle to oxidize free fatty acids for energy production. This versatile herb also helps the body adapt to stress by mediating the levels of certain adrenal hormones, most notably corticosterone. In addition, Panax ginseng is used in Herbal Medicine as a supportive therapy for the promotion of healthy glucose levels, which can be elevated during stress by the increased activity of adrenal hormones such as cortisol and epinephrine. Licorice extract is also included to help relieve inflammatory conditions of the gastrointestinal tract, soothing mucus membranes as a demulcent. Licorice is also traditionally used in Herbal Medicine as an expectorant to help relieve chest complaints, such as catarrhs, coughs and bronchitis.

NPN: 80062670

• Comprehensive formula containing vitamins, minerals and herbal extracts
• Supports healthy thyroid cell metabolism and thyroid hormone function
• Made with hypoallergenic, vegetarian ingredients

Thyroid Support Complex is a comprehensive formula containing vitamins, minerals and herbal extracts. It was specifically designed to support healthy thyroid gland function. Iodine is absorbed by the thyroid gland and supports the formation of triiodothyronine (T3) and thyroxine (T4) hormones. l-Tyrosine is also a key component in the synthesis of thyroid hormones. Healthy selenium levels have been associated with maintaining healthy thyroid cell metabolism, as well as thyroid hormone function. Doubling as a powerful antioxidant, selenium combines with vitamin C and curcuminoids to neutralize free radicals, including those that affect iodothyronine 5’-monodeiodinase enzyme activity, the limiting factor in the conversion of T4 to the more active T3 hormone. Thyroid Support Complex also contains standardized extracts from forskohlii, guggul and ashwagandha, herbs with an extensive history of traditional use.

NPN: 80026097

Formulated with Dr. Samuel F. Yanuck, an internationally recognized immunology thought leader and educator

• Part of the PureResponse™ Immune Protocol for healthy immune balance and function
• Contains a blend of berberine, Chinese skullcap, broccoli, ginger and zinc
• Supports healthy activation of Th1 cells to promote innate immunity and cell-mediated immune defences
• Maintains healthy immune biomarkers and cytokine balance related to cell tissue health and comfort

Berberine Immune Support is designed to maintain immune health by supporting healthy activation of Th1 cells, thereby promoting innate immunity and cell-mediated immune defences. Th1 responses are affected by stress, aging and cytokine changes resulting from metabolic, hormonal, physiological, and environmental factors. This product helps balance cytokine production in order to promote Th1 differentiation. Support for Th1 may be indicated for enhancement of natural defences. Berberine is a natural plant alkaloid that has been researched in clinical and preclinical studies, while ginger is a traditionally used and clinically studied herb. Zinc plays an important role in supporting the body’s defence system, promoting healthy neutrophil, natural killer cell, and T-lymphocyte function. This formula also offers skullcap and broccoli, which are primarily recognized for their bioactive constituents baicalin and sulforaphane, respectively.

NPN: 80089384

Formulated with Dr. Samuel F. Yanuck, an internationally recognized immunology thought leader and educator

• Part of the PureResponse^™ Immune Protocol for healthy immune balance and function
• Contains a blend of N-acetyl-l-cysteine (NAC), quercetin, perilla seed and astragalus extracts
• Astragalus is used in Herbal Medicine to help maintain a healthy immune system and as an adaptogen to help increase energy and resistance to stress

Perilla Plus w/ NAC is designed to support immune health by modulating the Th2 immune response, which helps maintain Th1/Th2 balance and support healthy self-tissue response and mucosal health. Th2 response is affected by stress, aging and cytokine changes resulting from metabolic, hormonal, physiological, and environmental factors. Th2 modulation may be indicated when addressing immune balance in the sinus, respiratory, urinary and intestinal tracts. Astragalus is used in Herbal Medicine to help maintain a healthy immune system. Preliminary research indicates that astragalus supports a healthy Th1/Th2 balance through modulation of Th2-associated cytokines, and helps support macrophage, natural killer (NK) cell and T-cell activity. Astragalus is also used in Herbal Medicine as an adaptogen to help increase energy and resistance to stress, helping to maintain a healthy immune system during periods of occasional physical or mental stress. Quercetin is known for its antioxidant activity, while N-acetyl-l-cysteine (NAC) promotes tissue levels of glutathione, a key component of the antioxidant defence system. Perilla seed offers a high source of polyphenols, rosmarinic acid, luteolin and other beneficial compounds compared to leaf.

NPN: 80090144

Formulated with Dr. Samuel F. Yanuck, an internationally-recognized immunology thought leader and educator

• Part of the PureResponse^™ Immune Protocol for healthy immune balance and function
• Contains clinically researched AP-Bio^™ andrographis
• Includes astragalus, which is used in Herbal Medicine to help maintain a healthy immune system
• Offers reishi mushroom beta glucans with immunomodulating properties

Innate Immune Support is designed to promote cell-mediated immune response, including NK cell and macrophage activity, and may be indicated for enhancement of natural defenses and mucosal health. Astragalus contains a variety of active constituents, including saponins and flavonoids, that contribute to its long tradition of use in Herbal Medicine to provide immune and cytokine balance support. In vitro and animal studies suggest that astragalus supports NK cell activity, as well as IgA and IgG levels in serum, key antibodies that play a critical role in mucosal immune defence. Reishi mushroom offers a rich source of polysaccharides to promote cell-mediated immunity. This formula includes both reishi mushroom fruiting body extract and reishi cultured mycelia extract, providing the unique and highly purified polysaccharide beta-1,3/1,6-glucan. This formula also includes a clinically researched extract of andrographis, an herb primarily known for its bioactive compound andrographolide and other diterpene lactones.

Formulated with Dr. Samuel F. Yanuck, an internationally recognized immunology thought leader and educator

Foundational support for healthy immune response, bone health and antioxidant status

• Part of the PureResponse^™ Immune Protocol for healthy immune balance and function
• Contains a blend of resveratrol, enhanced-absorption curcumin, black galingale, broccoli, quercetin and vitamin D
• Supports immune function and promotes cellular protection against free radicals
• Helps to build strong bones and teeth and prevent vitamin D deficiency

Balanced Immune is designed to support immune balance and tissue health, in part by targeting the NLRP and NF-κB pathways to modulate cytokine production. NLRP (NOD-like receptor proteins) act as intracellular sensors to oxidative and environmental stressors. Research suggests vitamin D supports healthy cellular response, in part by modulating this pathway. This formula provides cellular protection against oxidative stress by promoting numerous enzyme and gene transcription pathways. Resveratrol supports the activity of Nrf2, a transcription factor that supports cellular function by promoting protection against oxidative stress. Curcumin is included in this formula as clinically researched and patented Meriva^® curcumin-phosphatidylcholine complex, which offers enhanced efficiency of absorption and resistance to degradation in the digestive tract. Pharmacokinetic data suggests a 20-fold increase in relative absorption compared to standard curcumin. Balanced Immune also offers broccoli, which is primarily recognized for its bioactive constituent sulforaphane, and SIRTMAX^® black galingale extract, which has been studied in a double-blind, placebo-controlled, crossover study.

NPN: 80090215

Supports antioxidant defence and detoxification

• Supports function of the liver, an organ involved in detoxification
• Provides antioxidants that help protect cells against free radicals

DIM & Detox offers support for antioxidant defence and function of the liver, an organ essential to the body’s detoxification. BioResponse DIM^® provides 25 mg per serving of a highly absorbable form of DIM, an important metabolite of indole-3-carbinol. DIM supports the expression of antioxidant and phase II detoxifying enzymes, which protect tissues from oxidative stress, toxins and reactive substances. Alpha lipoic acid and N-acetyl-L-cysteine (NAC) also provide antioxidants for cellular protection and act to support phase II detoxification enzyme activity in the liver. l-Methionine is an essential amino acid that supports glutathione production and encourages healthy liver function, including phase II detoxification pathways, healthy hepatic fat metabolism, and bile flow. The amino acid taurine is also present in liver cells as an important component of bile acids, which aid in the absorption of fat-soluble vitamins.

NPN: 80073707

Supports cognitive function and restful sleep during stress

Cortisol Calm is a blend of herbal extracts, including Sensoril® ashwagandha, rhodiola and magnolia, plus vitamin D and l-theanine – the bioactive compound originally found in green tea. Cortisol, released in response to stress, is mainly produced by the adrenal cortex. Intra-abdominal adipocytes also produce cortisol. Identified as an adaptogen through extensive research, rhodiola helps to temporarily relieve symptoms of stress (such as mental fatigue and sensation of weakness) by maintaining healthy adrenal cortisol activity. Recently, a double-blind crossover study examined the effect of rhodiola on mental performance in healthy physicians. The results suggest that rhodiola may help to moderate fatigue under stressful conditions and to support cognitive function, including mental focus and stamina. In a separate, double-blind, placebo-controlled pilot study, rhodiola provided support for physical and mental stress in students. Promoting the proper activity of neurotransmitters such as serotonin, norepinephrine and dopamine plays a part in this herb’s ability to support cognitive functioning, memory and attention. Cortisol Calm also contains Sensoril^® ashwagandha, a clinically researched form of the herb. Ashwagandha is traditionally used in Ayurveda for memory enhancement and as a sleep aid. As stress may also decrease immune responses over time, vitamin D is included to help maintain immune function, including immune cell maturation, differentiation and migration.

• Rhodiola is used in Herbal Medicine to support cognitive function and as an adaptogen to help temporarily relieve symptoms of stress
• Ashwagandha is traditionally used in Ayurveda for memory enhancement and as a sleep aid
• Vitamin D maintains immune function

NPN: 80075253